Factores de riesgo asociados a reacción adversa hepática por fármacos de primera línea contra Mycobacterium tuberculosis

Abstract

Epidemiological control of tuberculosis (TB) requires a highly efficient therapy, to be able to eliminate transmission of tuberculosis. Adverse drug reactions (ADR) contribute to decrease the efficiency of treatment. Hepatic ADR is the most feared and can become fatal and has been related to risk factors such as advanced age, female gender, non-caucasian ethnic groups, characteristics of enzymatic metabolism of drugs, drug associations, presence of hepatitis B, C and HIV virus infections, malnutrition, kidney transplants, pregnancy, puerperium and alcohol consumption. There are no guidelines for monitoring liver function on a regular basis. Therefore a close monitoring of the appearance of symptoms suggestive of liver toxicity is recommended. In some conditions of high risk of hepatic ADR, clinical judgment could indicate the biochemical monitoring of liver function.